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Nuclear contrast threshold, minimum nuclear intensity, and nuclear size were determined using the pre-trained Nuclear Segmentation algorithm (AI default) and kept constant for the entire analysis

Ang II and ET-1, via G-protein-coupled receptors, activate growth factor receptors including IGF-1, PDGF, and EGF, thereby increasing redox-dependent vascular processes such as vascular remodeling, inflammation, medial hypertrophy, and fibrosis (63)